Metagenics SPM Active
Background
Our bodies respond to inflammation and tissue damage by producing molecules called specialized Pro-resolving mediators (SPMs) which help resolve inflammation and promote tissue repair. SPMs are an integral part of resolving inflammation and helping restore normal functions of inflamed tissues and cells. However, factors such as diet, lifestyle, and excess body fat can affect adequate production of these important molecules which further highlights the need for supplementation from exogenous sources.
What SPM Active offers
Affiliated links to buy Metagenics SPM Active
Amazon: Available with 60-Softgels and 120-Softgels
This product offers 1g of SPMs that are extracted from high quality marine oil through a patented process called fractionation. After vigorous testing, fractions high in SPMs are selected and tested to ensure their safety and their efficacy in pro-resolving activity.
Similar to other Metagenics products, costumers are able to enter the lot number of their product in the following website and examine the level of toxins and pollutants contained in that specific batch. To ensure the highest level of care and quality, all product testing is facilitated through independent third party laboratories.
Why SPM Active
Metagenics was the first company to market and deliver SPMs as a supplement in North America and this product is the more concentrated and improved formulation of the original. In 2 separate case studies, athletes were supplemented with SPM active and asked to self-report their mood and level of fatigue and pain. Following daily intakes of SPMs for 8 weeks, participants showed the following changes: significant decrease in pain levels immediately and 24 hours after workouts; increase in emotional wellbeing score measured in categories such as depression, tension and confusion; significant decrease in fatigue and stress and bodily discomfort. Additionally, due to their role in immune response mitigation in the resolution phase of stress or injury to tissues and cells, this product is ideal for people with inflammatory diseases or unresolved injuries.
To summarize, previous research has shown SPMs to be beneficial in the following ways: reducing inflammation which can be helpful in inflammatory conditions such as rheumatoid arthritis, asthma, and cardiovascular disease; promoting tissue regeneration and repair by activating stem cells and promoting angiogenesis (formation of new blood vessels); enhancing immune function by promoting bacterial clearance and increasing lymphocyte (type of white blood cell) function.
Score being calculated and collected by Suptamins for Metagenics SPM Active
Category | Sub Category | Score |
|---|---|---|
Suptamin's Static Score | Form of the molecule found in product: | 1 |
Suptamin's Static Score | Presence of ingredient enhancing absorption | 0 |
Suptamin's Static Score | Unwanted ingredients and additives su | 1 |
Suptamin's Static Score | Clinical studies supporting the use of the product | 1 |
Suptamin's Static Score | Appropriate dosage and safety of taking the medication | 1 |
Suptamin's Static Score | Quality of ingredients and whether they are third party tested | 2 |
Suptamin's Static Score | Total score, out of 10 | 6 |
Suptamins Past Consumers Score | 3rd party, Amazon score, out of 10 | 0 |
Suptamins Past Consumers Score | Suptamins customers score | 0 |
Suptamins Past Consumers Score | Total score, out of 10 | 0 |
Suptamins Real Time Score | Effectiveness | 0 |
Suptamins Real Time Score | Quality | 0 |
Suptamins Real Time Score | Aggregate Customer rating | 0 |
Suptamins Real Time Score | Price | 0 |
Suptamins Real Time Score | Empirical data | 0 |
Suptamins Real Time Score | Total score, out of 10 | 0 |
Dosage and precautions for SPM Active
Directions: Take two softgels once daily or as directed by your healthcare practitioner.
Caution: If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
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SPM Active ingredients
Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
Serving Size: 2 softgel | ||
Calories | 10 | |
Total Fat | 1 g | 1% |
Cholesterol | <5 mg | <2% |
^Active Fractionated Marine Lipid Concentrate | 1 g | ** |
Fractionated marine lipid concentrate fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)
Softgel shell contains gelatin, glycerin,and water
SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA) and 14-hydroxy-docosahexaenoic acid (14-HDHA).
Other Ingredients: Silica, Fish (anchovy, sardine, and mackerel)
Serving Size: 2 Softgels
This product is non-GMO and gluten-free.
Servings Per Container: 30. Other serving sizes might also be available.
*Percent Daily Values are based on a 2,000 calorie diet.
**Daily Value not established.
References about SPM Active
Third parties review for Metagenics SPM Active
- Hong S, Lu Y, Tian H, et al. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. Am J Physiol Cell Physiol. 2014;307(11):C1058-C1067. doi: 10.1152/ajpcell.00184.2014
Zhang MJ, Sansbury BE, Hellmann J, et al. Resolvin D2 enhances postischemic revascularization while resolving inflammation. Circulation. 2016;134(9):666-680. doi: 10.1161/CIRCULATIONAHA.115.020343
Levy BD, Kohli P, Gotlinger K, et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol. 2012;189(4):1983-1991. doi: 10.4049/jimmunol.1201230
Fredman G, Tabas I. Boosting inflammation resolution in atherosclerosis: the next frontier for therapy. Am J Pathol. 2017;187(6):1211-1221. doi: 10.1016/j.ajpath.2017.02.013
Dalli J, Serhan CN. Pro-resolving mediators in regulating and conferring macrophage function. Front Immunol. 2017;8:1400. doi: 10.3389/fimmu.2017.01400
Serhan CN, Chiang N, Dalli J, Levy BD. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014;7(2):a016311. doi: 10.1101/cshperspect.a016311